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Original articles 2019

The most visible original articles of the year with first or last authors from the medical faculty (without reviews, letters, case reports, comments or news).

Bauer, A1, Klemm, M1, Rizas, KD1, Hamm, W1, von Stülpnagel, L1, Dommasch, M, Steger, A, Lubinski, A, Flevari, P, ..., Zabel, M
Prediction of mortality benefit based on periodic repolarisation dynamics in patients undergoing prophylactic implantation of a defibrillator: a prospective, controlled, multicentre cohort study.
Lancet 2019; 394: 1344-1351 (JIF2018 59,1)
1 Medizinische Klinik und Poliklinik I

Renkawitz, J1, Kopf, A, Stopp, J, de Vries, I, Driscoll, MK, Merrin, J, Hauschild, R, Welf, ES, Danuser, G, ..., Sixt, M
Nuclear positioning facilitates amoeboid migration along the path of least resistance.
Nature 2019; 568: 546-550 (JIF2018 43,1)
1 Institut für Chirurgische Forschung

Silvestre-Roig, C1, Braster, Q1, Wichapong, K, Lee, EY, Teulon, JM, Berrebeh, N, Winter, J1, Adrover, JM, Santos, GS, ..., Soehnlein, O1
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
Nature 2019; 569: 236-240 (JIF2018 43,1)
1 Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten

Pan, C, Schoppe, O, Parra-Damas, A, Cai, R, Todorov, MI, Gondi, G1, von Neubeck, B, Bögürcü-Seidel, N, Seidel, S, ..., Ertürk, A2
Deep learning reveals cancer metastasis and therapeutic antibody targeting in the entire body.
Cell 2019; 179: 1661-1676.e19 (JIF2018 36,2)
1 Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde
2 Institut für Schlaganfall- und Demenzforschung

Guan, S1, Munder, A, Hedtfeld, S, Braubach, P, Glage, S, Zhang, L1, Lienenklaus, S, Schultze, A1, Hasenpusch, G, ..., Rosenecker, J1
Self-assembled peptide-poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis.
Nat Nanotechnol 2019; 14: 287-297 (JIF2018 33,4)
1 Kinderklinik und Kinderpoliklinik im Dr. von Hauner'schen Kinderspital

Yin, C1, Ackermann, S, Ma, Z1, Mohanta, SK1, Zhang, C1, Li, Y1, Nietzsche, S, Westermann, M, Peng, L, ..., Habenicht, AJR1
ApoE attenuates unresolvable inflammation by complex formation with activated C1q.
Nat Med 2019; 25: 496-506 (JIF2018 30,6)
1 Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten

Klopstock, T1, Tricta, F, Neumayr, L, Karin, I1, Zorzi, G, Fradette, C, Kmiec, T, Büchner, B1, Steele, HE, ..., Vichinsky, E
Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension study.
Lancet Neurol 2019; 18: 631-642 (JIF2018 28,8)
1 Neurologische Klinik und Poliklinik

Levin, J1, Maaß, S, Schuberth, M1, Giese, A2, Oertel, WH, Poewe, W, Trenkwalder, C, Wenning, GK, Mansmann, U3, ...,Höglinger, GU
Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial.
Lancet Neurol 2019; 18: 724-735 (JIF2018 28,8)
1 Neurologische Klinik und Poliklinik
2 Institut für Neuropathologie
3 Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie

Modest, DP1, Martens, UM, Riera-Knorrenschild, J, Greeve, J, Florschuetz, A, Wessendorf, S, Ettrich, T, Kanzler, S, Noerenberg, D2, ..., Geissler, M
FOLFOXIRI plus Panitumumab as first-line treatment of RAS wild-type metastatic colorectal cancer: The randomized, open-label, phase II VOLFI study (AIO KRK0109)
J Clin Oncol 2019; 37: 3401- (JIF2018 28,2)
1 Medizinische Klinik und Poliklinik III
2 Klinik und Poliklinik für Radiologie

Modest, DP1, Fischer von Weikersthal, L, Decker, T, Vehling-Kaiser, U, Uhlig, J, Schenk, M, Freiberg-Richter, J, Peuser, B, Denzlinger, C, ..., Heinemann, V1 ,
Sequential versus combination therapy of metastatic colorectal cancer using Fluoropyrimidines, Irinotecan, and Bevacizumab: a randomized, controlled study-XELAVIRI (AIO KRK0110).
J Clin Oncol 2019; 37: 22-32 (JIF2018 28,2)
1 Medizinische Klinik und Poliklinik III

Seijkens, TTP1, Poels, K, Meiler, S, van Tiel, CM, Kusters, PJH, Reiche, M, Atzler, D1, Winkels, H, Tjwa, M, ..., Lutgens, E1
Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death.
Eur Heart J 2019; 40: 372-382 (JIF2018 23,2)
1 Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten

Aradi, D, Gross, L1, Trenk, D, Geisler, T, Merkely, B, Kiss, RG, Komócsi, A, Dézsi, CA, Ruzsa, Z, ..., Sibbing, D1
Platelet reactivity and clinical outcomes in acute coronary syndrome patients treated with prasugrel and clopidogrel: a pre-specified exploratory analysis from the TROPICAL-ACS trial.
Eur Heart J 2019; 40: 1942-1951 (JIF2018 23,2)
1 Medizinische Klinik und Poliklinik I

de Juan, A1, Ince, LM1, Pick, R1, Chen, CS1, Molica, F, Zuchtriegel, G1, Wang, C, Zhang, D, Druzd, D1, ..., Scheiermann, C1
Artery-associated sympathetic innervation drives rhythmic vascular inflammation of arteries and veins.
Circulation 2019; 140: 1100-1114 (JIF2018 23,1)
1 Institut für Chirurgische Forschung

Eze, C1, Käsmann, L1, Manapov, F1
Redefining the role of prophylactic cranial irradiation in the modern era of active surveillance in small cell lung cancer.
JAMA Oncol 2019; 5: 11-12 (JIF2018 22,4)
1 Klinik und Poliklinik für Strahlentherapie und Radioonkologie

Adrover, JM, Del Fresno, C, Crainiciuc, G, Cuartero, MI, Casanova-Acebes, M, Weiss, LA, Huerga-Encabo, H, Silvestre-Roig, C1, Rossaint, J, ..., Hidalgo, A1
A Neutrophil Timer Coordinates Immune Defense and Vascular Protection.
Immunity 2019; 50: 390-402.e10 (JIF2018 21,5)
1 Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten

Cai, R1, Pan, C1, Ghasemigharagoz, A, Todorov, MI1, Förstera, B1, Zhao, S1, Bhatia, HS1, Parra-Damas, A1, Mrowka, L1, ..., Ertürk, A1
Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections.
Nat Neurosci 2019; 22: 317-327 (JIF2018 21,1)
1 Institut für Schlaganfall- und Demenzforschung

Parhizkar, S1, Arzberger, T2, Brendel, M3, Kleinberger, G1, Deussing, M3, Focke, C, Nuscher, B1, Xiong, M, Ghasemigharagoz, A, ..., Haass, C1
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Nat Neurosci 2019; 22: 191-204 (JIF2018 21,1)
1 Adolf-Butenandt-Institut, Lehrstuhl für Stoffwechselbiochemie
2 Klinik und Poliklinik für Psychiatrie und Psychotherapie
3 Klinik und Poliklinik für Nuklearmedizin