A large part of cutting-edge medical research relies on state-of-the-art technology. Equally important is experience in the operation of such large equipment as well as in the evaluation and interpretation of the data obtained. Research Core Facilities provide access to highly specialized services, equipment, and staff that would otherwise be too expensive for an individual laboratory to support. The Faculty of Medicine operates a large number of large-scale equipment that is either partially or entirely devoted to research. Physicians, biologists, chemists, bioinformaticians and technicians use these devices.
The Faculty of Medicine offers access to sequencing, flow cytometry, mass spectrometry, bioimaging as well as biobanks.
Not even computer technology is progressing as rapid as gene sequencing and genome analysis. If the decryption of the first human genome cost billions of dollars and took years, today's commercial sequencers deliver almost automatically and in parallel a whole number of sequences - at the cost of a more complex MRI. Therefore, it is all the more important for a large research institution to benefit from the advantages of the new device generations, but also to preserve the established know-how through the technology cycles.
Flow cytometry, the measurement of the properties of cells that flow through a thin channel in rapid succession, is a standard method in biomedical research. With multi-colored laser light a plurality of properties of a cell can be detected at the same time. Some flow cytometers can also sort the analyzed cells so that they can be processed separately with the cells of a certain type.
In a mass spectrometer, the contents of a sample are separated and recognized according to their specific molecular weight. Thus, without complex chemical analyzes, the composition of a sample can be determined very accurately and examined for the slightest trace of certain substances.
An inter-institutional biobank at the Faculty of Medicine is currently being set up. Researchers from the preclinical facilities and the university hospital have access to the decentrally organised sample collections via a central catalog. The catalog makes available samples of the cooperating decentralized biobanks visible and allows samples to be ordered there. The decentralized biobanks put together the required samples and pass them on to the scientists in pseudonymised or anonymous form. The catalog is updated on a regular basis (about once a week) on available samples.
To provide scientists access to cutting-edge biomolecular instrumentation and the concomitant technical expertise, the research consortium Biomedical Center, an association of preclinical chairs of the Faculty of Medicine runs core facilities for Bioinformatics, Protein Analytics, Bioimaging, Flow Cytometry and Biophysics, as well as operating a state-of-the-art animal experimentation facility.