ERC Starting Grant - Adapting protein fate for muscle function and fitness (Proteofit)
- Project leader: Prof. Dr. Alexander Bartelt
- Affiliation: Institute of Cardiovascular Prevention
- Funding: 2020 to 2025
In his ERC project on Adapting Protein Fate for Muscle Function and Fitness (acronym: PROTEOFIT), Alexander Bartelt will study, at the molecular level, how we can improve the function of muscle proteins for enhanced exercise and protection from metabolic disease. The project investigates the dynamic regulation of protein degradation in enabling the musculature to meet the metabolic and physiological demands associated with enhanced physical activity. By characterizing the targets of protein degradation in physically fit and obese humans, the results will contribute to the development of new approaches to the treatment of metabolic disorders such as atherosclerosis, diabetes and obesity.
Alexander Bartelt is a biochemist and molecular biologist by training. He received his PhD from Hamburg University where he studied the metabolis of brown adipose tissue. He completed his postdoctoral training Harvard T.H. Chan School of Public Health in Boston, where he worked on the immunometabolic responses of brown adipose tissue to stress. Since 2018 Bartelt has been leading a German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung) Junior Research Group and in 2019 he was appointed Professor of Cardiovascular Metabolism. Bartelt is a member of the Collaborative Research Center (SFB) 1123 and his excellent research was recognized by national and international awards, stipends, and fellowships.