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Else Kröner Fresenius Clinical Research School - Rare immune system diseases

  • Speaker: Prof. Dr. Christoph Klein
  • Affiliation: Kinderklinik und Kinderpoliklinik im Dr. von Hauner'schen Kinderspital
  • Funding: 2014 to2022

The Research College "Rare Diseases of the Immune System - from Pathophysiology to the Development of New Therapeutic Strategies" is a program of excellence for outstanding young scientists with a focus on pediatrics.

Based on clinical observations and problems of rare monogenic diseases, translational scientific projects in immunology and its borderline areas will be developed. The focus of the program is on monogenic diseases of the immune system - from classical primary immunodeficiencies to inflammatory diseases and diseases with organ-specific inflammation and specific susceptibility to defined microbial pathogens. In particular, the research fields of transcriptional control of gene expression, vesicular transport processes, epigenetics and genomic integrity will be investigated using novel human immunodeficiency diseases as examples. Based on clinical observation, not only experimental model systems will be developed, but also the foundations for innovative therapeutic strategies will be laid (designer nucleases, influencing protein folding, antibody-based immunotherapy).

The Else Kröner Forschungskolleg will have a formative influence on the further development of translational research in pediatrics beyond the Munich location.

Physicians during their residency training who are released for research purposes via the "Else Kröner Fresenius Clinical Research School Munich" program and who fulfill the requirements for the MCS program may be admitted to Track 3 of the MCSP upon application. Admission of applicants is subject to individual review by the MCSP Selection Committee. For more information, see MCSP Track 3 (assoziierte Clinician Scientists).

Source: Universitätsklinikum München (Text)